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Opioid use disorder induces oxidative stress and inflammation

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ROS can oxidize organelles, nucleic acids, proteins and lipids, which results in cellular damage [51]

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Idiopathic inflammatory diseases Necrotizing meningoencephalitis and necrotizing leukoencephalitis of Pugs and other small-breed dogs Canine necrotizing meningoencephalitis (NME), formerly Pug dog encephalitis, is an idiopathic disease affecting mainly Pug dogs, but also reported rarely in the Maltese, Pekingese, Shih Tzu, and Chihuahua

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doi: 10.1159/000430271

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9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

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