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PMID: 129 JinD-YChenXLiuYWilliamsCMPedersenLCStaffordDWet al

Similar content being viewed by others Introduction As of November 21st, 2021, over 257 million cases of coronavirus disease 2019 (COVID-19) have been reported, and more than 5 million lives claimed globally [1]

2018;8:13675 Modahl C, Fein D, Waterhouse L, Newton N

The depletion of DJ-1 increases the vulnerability of mitochondria to neurotoxic insults which mimic PD pathology [38,39], whereas overexpression of DJ-1 improves intracellular antioxidants and protects neurons [38,40,41]

Figure 2 Several studies in recent years have shown that silencing TRFC (the gene encoding TFR1) inhibits erastin-induced iron apoptosis and prevents LIP accumulation, whereas the heme oxygenase HO-1 increases intracellular free iron levels and promotes heme degradation, which speeds up the ferroptosis process (78, 79)