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While GLP-1 agonists primarily affect the pancreas and gut to regulate insulin secretion and gastric emptying, cagrilintide acts on the brain to suppress appetite and food intake

Berlec A, Skrlec K, Kocjan J, Olenic M, Strukelj B (2018) Single plasmid systems for inducible dual protein expression and for CRISPR-Cas9/CRISPRi gene regulation in lactic acid bacterium Lactococcus lactis

Nakagaki K, Ebihara S, Usui S, Honda Y, Takahashi Y, Kato N

Achieve up to 30% weight loss Reach an A1C under 7% or lower Mechanism of Action Ozempic is a glucagon-like peptide-1 receptor agonist

The results also confirm the validity of this cell culture model