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The phenylalanine/tyrosine ratio also reflects immune activation status, and studies have identified phenylalanine and histidine metabolism as among the most markedly altered in sepsis (120,125)

Saxagliptin alleviates erectile dysfunction through increasing stromal cell-derived factor-1 in diabetes mellitus

Herpesvirus reactivation or prothrombotic tendency, however, may be important limitations

This has led to an encouraging clinical trial for the treatment of MS with temelimab, an anti-HERV monoclonal antibody (87)

Specific combinations, such as docetaxel and trametinib, have been investigated in KRAS G12C cases with TP53 co-mutations, which did not improve the treatment efficacy in KRAS-mutant patients, highlighting the challenge for tailored co-mutation-targeted therapies [198]