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418,419 Studies have also shown that polyphenols in tea significantly alleviate UC by preventing the destruction of colorectal intestinal structure and function and inhibiting the expression of inflammatory factors

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In contrast topical application of 15d-PGJ 2 on skin wounds in diabetic mice increases the expression of peroxisome proliferator-activated receptor gamma (PPAR) in macrophages at the wound site, thus reducing inflammation and accelerating wound closure [198]
