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In contrast to the above hypothesis, work in the EAE model suggests that agonism of Hcar2 leads to a G i/o signalling cascade in which the PLC pathway is activated

Cytokines and growth factors in the developing intestine and during necrotizing enterocolitis

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These disorders include fatty liver syndromes such as MAFLD and MASH, hyperlipidemia, lactic acidosis, ketoacidosis, and hyperuricemia