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Concomitant treatment of melatonin and folic acid supplementation restores the enzymatic activity of superoxide dismutase and significantly reduces lipid peroxidation in the RIM rats [79]

However, it has been reported that the use of aromatase inhibitors resulted in reduced hot flushes as compared to GnRH agonist, while the adverse effect of aromatase inhibitors are usually mild and occurs more frequently with prolonged use

Epidemiological evidence has associated the use of therapeutic APAP doses with the risk of chronic obstructive pulmonary disease (COPD) and asthma

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Indeed, oxidative stress-induced DNA damage has been documented in diabetes [51]