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J Cell Sci (2012) 125:7959

Human timelines are less established due to limited clinical trials, but case reports suggest symptom improvement within 23 weeks of subcutaneous administration." question : "Is oral KPV effective for ulcerative colitis, and what is the correct dosage?" answer : "Oral KPV has demonstrated efficacy in a Phase II ulcerative colitis trial at 10mg three times daily for 8 weeks, achieving 38% endoscopic remission vs 12% placebo

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The large amount doesn't pose a danger because people with pernicious anemia absorb only a small fraction of it