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Acknowledgements We appreciate the contributors to the public databases and all patients enrolled in our research

doi: 10.1016/j.ebiom.2023.104481 [DOI] [PMC free article] [PubMed] [Google Scholar] 240.Igarashi M, Nakagawa-Nagahama Y, Miura M, et al

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found that cyclooxygenase 2 (COX-2)-expressing fibroblasts can produce prostaglandin E2 (PGE2) to drive dysfunctional dendritic cells (DCs) and suppressive monocytes

However, about 1-2% of the electrons slip through complexes I and III of the ETC, after which they react with molecular oxygen to sequentially form ROS such as O 2 - , HO 2 and H 2 O 2 [5,11-13]