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For hot flashes specifically, the evidence is modest but present

En 2015, un estudio nutricional evalu a 52 hombres y mujeres sanos, de entre 20 y 40 aos de edad, para ver si los hongos shiitake mejoraban su sistema inmunolgico

Simultaneous treatment with L-carnitine attenuates the renal fibrosis (which correlated with a reduction of plasma TGF-1 levels) and the pro-oxidative and proinflammatory status reported in L-NAME groups, with a concomitant increase in the expression of PPAR- [4]

It may help cancer-related cachexia by reducing proteasome activity (50) , but studies in humans are needed