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During ischemic stroke, there is an increase in the production of arachidonic acid, increased expression of ACSL4, increased production of proinflammatory cytokines in brain tissue, neuroinflammation, enlargement of the infarct area, cell death by ferroptosis, and deterioration of the clinical condition

[link] R Carter, H Woolfenden, A Baillie, S Amsbury, S Carroll, E Healicon, S Sovatzoglou, SA Braybrook, JE Gray, J Hobbs, RJ Morris, AJ Fleming, "Stomatal Opening Involves Polar, Not Radial, Stiffening Of Guard Cells", Current Biology 27 (19): 2974-2983.e2 (2017)

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Dodson M, Shakya A, Anandhan A, Chen J, Garcia JGN, Zhang DD

Based on a systematic review of existing literature, this article comprehensively summarizes how ROS is generated from both endogenous and exogenous sources