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Several factors can lead to a lax LES and contribute to the development of GERD, including: Increased intra-abdominal pressure (IAP) - obesity, pregnancy

There is still a gap in existing research in the field, necessitating well-designed, robust, multicenter clinical trials, with sensitive endpoints and standardized protocols to facilitate the diagnosis of DPN via a simple and effective algorithm and to track progression of disease and treatment response

Yet, there are still many challenges ahead for preclinical studies and outstanding questions to address to move the field forward

LPS/ATP stimulation resulted in mitochondrial fragmentation as well as cristae disorganization, while GYY4137 pretreatment properly protected the mitochondrial structure of macrophages with a well-preserved double membrane structure and intact cristae (Fig