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as well as ANK1 (for ankyrin 1, erythrocytic), located on chromosome 8p11.1

Hsiang CY, Cheng HM, Lo HY, Li CC, Chou PC, Lee YC, Ho TY (2015) Ginger and zingerone ameliorate lipopolysaccharide-induced acute systemic inflammation in mice, assessed by nuclear factor-B bioluminescent imaging

doi: 10.1177/0883073815583688

It plays a role in nearly every system in the body, from bone density to immune function

In T cells of SLE patients, mTOR activation triggers ROS production, while SIRT2 concurrently upregulates IL-17A expression in these cells by modulating the mTOR complex 1 (mTORC1)/HIF-1/RORt signaling pathway, thereby contributing to the pathogenesis of SLE (101, 155)