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Another (very small study) found that combining biotin with a probiotic supplement, alongside a targeted topical gel appeared to safely reduce acne and improve skin health over 2 months in people with mild to moderate acne

Although some of the supplement doses are very high (for instance, 500 or 1,000 micrograms when a healthy adult only needs 2.4 micrograms per day), your body only absorbs what it needs and pees the rest out