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Copper delivery through skin can provide beneficial effects but its potential to induce skin irritation reactions is often overlooked

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10.1016/j.eururo.2014.07.035 85 Hummel-EisenbeissJ.HascherA.HalsP.-A.SandvoldM
The APPswe/Ind (J20) mouse, which has two mutations in the human APP gene, was modified further to make a third mutation by replacing Met631 by leucine (M631L) in the APP gene, which corresponded to replacing Met35 of A42 with Leu
