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Whilst many of these closed-loop platforms remain in early-stage research or preclinical testing, their potential to reduce therapeutic lag, improve adherence, and mitigate risks associated with over- or under-dosing is substantial [157]

Environmental exposure to polychlorinated biphenyls (PCBs) and breast cancer: a systematic review of the epidemiological evidence

Direct oxidation of GSH to GSH through free radical intermediates formed from 15-HpETE-PE before it is metabolized could also occur

Besides, numerous studies have showed that inhibition of GPX4 could increase the sensitivity of chemotherapy, radiotherapy, immunotherapy and nanotherapy by inducing lipid peroxidation and ferroptosis [227229]