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Vigorous shaking can physically damage them, a process known as shearing

Regul Pept 2010

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Results The copper level is elevated in kidney fibrotic tissue We assessed the levels of some metal ions in the kidney tissue of the uIRIx (unilateral kidney ischemia/reperfusion injury with contralateral nephrectomy, sacrificed at 28 days) induced renal fibrosis model and found that only copper level was significantly increased, but not other metal ions, such as zinc, magnesium, manganese, iron, chrome, and calcium, determined by inductively coupled plasma-mass spectrometry (ICP-MS), compared to that in the sham mice (Fig