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The mean maximum serum trimethoprim concentration was higher and mean renal clearance of trimethoprim was lower in geriatric subjects compared with younger subjects [see Clinical Pharmacology (12.3)]
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Prodrug design to improve pharmacokinetic and drug delivery properties: challenges to the discovery scientists
doi: 10.18632/aging.204007
doi:10.1016/j.mito.2019.02.002 21
