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An even less likely theory suggests dysfunction of methylmalonyl-CoA mutase, which as an important detoxifying enzyme, is highly expressed in most tissues, including the nervous system [40]

Mini Rev Med Chem 18:10951109

Martinez FO, Sica A, Mantovani A, Locati M

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Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinsons disease
