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Loren Pickart estimated that toxic effects would begin at approximately 22,500 mg, which represents a 300-fold margin above effective therapeutic doses

An overview on GPCRs and drug discovery: structure-based drug design and structural biology on GPCRs

Hu CL, Nydes M, Shanley KL, Morales Pantoja IE, Howard TA, Bizzozero OA

Unlike L-DOPA, this approach did not trigger dyskinesia

Glutaredoxin 2 prevents aggregation of mutant SOD1 in mitochondria and abolishes its toxicity