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Description
Alpha-Lipoic Acid (ALA): Supports glutathione regeneration and enhances its antioxidant effects
Nrf2 is the key transcription factor required for activation of ARE
Some researchers use both, with topical for local effect and injection for systemic support
In addition, GSSG retained in mitochondria during oxidative stress can lead to the S-gluthionylation of target proteins with mitochondrial dysfunction (20, 21)
doi: 10.1158/1535-7163.MCT-08-0625
