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Inhibition of human cytochrome P450 activities by kava extract and kavalactones

Briefly, in a 200 l reaction volume, 5 g ml 1 recombinant GSTO1 in reaction buffer (100 mM Tris (pH 8.0), 1.5 mM EDTA and 1 mM DTT) was incubated with DMSO or different concentrations of inhibitors for 30 min at 37 C

Single-atom Ca nanozyme induces glioma death through Ca(2+)-overload-enhanced catalytic tumor nanotherapy, ferroptosis and synergistic remodeling of the immune microenvironment

Chronic ethanol consumption can lead to mitochondrial dysfunction, which increases mitochondrial permeability and causes the release of pro-apoptotic factors

However, mTORC1 inhibitors do not counteract L-citrulline-induced stimulation of muscle protein synthesis [105]