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[PubMed] Yamada KA, Tang C-M

4.3.3 Therapeutic interventions and limitations Experimental and early clinical studies suggest that restoring magnesium homeostasis may attenuate alcohol-associated inflammatory responses

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This agrees with results of X-ray crystallography binding studies performed by Tanner et al, (2001, 2004, 2007) which demonstrate that anti-ssDNA mouse monoclonal antibody requires only thymidine pentamer for high affinity binding .This was used as a principal (physical-chemical bases) (Figure 1a) for our magnetic beads design, and has been confirmed to function in the case of human normal, SLE and B-CLL antibodies from plasma

It is worth noting that the C-terminal leucine zipper motif is linked to c-MET with sufficient flexibility that is unlikely to impose the distance restraints between the two c-METs