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Pigmentation concerns

Due to the high mutation rate of malignant cells with defects in the p53 pathway and the fact that mutant p53 proteins are only highly expressed in malignant tissues but absent in normal tissues, targeting mutant p53 itself has been proposed to be a promising strategy for improving the treatment of chemo- and/or radio-resistant tumours

Some users employ daily dosing during particularly stressful periods but cycle off regularly

Therapy-induced senescent cells can re-enter the cell cycle to show aggressive proliferative and cancer stem-like properties, presenting a risk for recurrence and treatment resistance