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Li BG, Hasselgren PO, Fang CH, Warden GD (2004) Insulin-like growth factor-I blocks dexamethasone-induced protein degradation in cultured myotubes by inhibiting multiple proteolytic pathways: 2002 ABA paper

L-Glutathione:Considered the master antioxidant because of its ability to protect the body's cells from oxidative damage

Furthermore, IL-1 induces apoptosis in pancreatic cells through the activation of the NF-B pathway, exacerbating cell loss [570]

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ROS-dependent nerve dysfunction seems to be related to neurovascular defects associated with hypoxia.21 Increased activity of NADPH oxidase has been detected in the retina of diabetic rats, thus suggesting a role of increased oxidative stress also in retinopathy.22 In patients with diabetes, endothelial cells are the main source of ROS, which overwhelm the cellular antioxidant capacity and impair cellular function.23 Impaired endothelium dependent vasodilatation has been demonstrated in vascular beds in patients with type 1 and type 2 diabetes.24 In addition, vascular smooth muscle cell function is impaired with a reduction of response to circulating vasodilators in subjects with diabetes mellitus.25 Oxidative stress also induces proliferation of vascular smooth muscle cells and promotes their migration into atherosclerotic lesions