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Here we identified dietary cholesterol-induced ferroptosis and the downregulation of peroxisome proliferator-activated receptor delta (PPAR) as central drivers of MASH pathogenesis

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( 4 Clinical testing and assessment related to ferroptosis 4.1 Biomarkers 4.1.1 Definition and mechanism of ferroptosis biomarkers Ferroptosis, as a novel form of programmed cell death, involves complex mechanisms and multiple biomolecules and metabolic pathways ( 4.1.2 Markers related to iron metabolism and ferroptosis Iron-related protein levels represent important biomarkers for assessing ferroptosis activity

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Importantly, early studies demonstrate a correlation between GSH deficiency and mitochondrial damage 60
