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Metabolic Effects: Adipose Tissue Regulation and Energy Balance

K-means clustering analysis of amplicon sequence variants by animal demonstrated that NNMTi-treated DIO mice switched to LD had a distinct microbiome pattern that was highlighted by decreased Erysipelatoclostridium and increased Lactobacillus relative abundances compared to vehicle counterparts

It is commonly investigated in preclinical research models relating to metabolic signalling pathways, cellular energy regulation, and enzymatic activity associated with nicotinamide N-methyltransferase (NNMT) interaction studies