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There is ample evidence to indicate that L-glutamine is the essential dietary supplement to help maintain mucosal integrity and barrier function under physiologic and pathophysiologic conditions

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330 Mechanistically, IFN activates the JAK/STAT1/interferon regulatory factor 1 (IRF1) signaling pathway and promotes IRF1 to bind to the IFN-stimulated response elements in the ACSL4 promoter region, ultimately leading to ACSL4 transcriptional upregulation in cancer cells