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However, considerable hyperpigmentation in the form of brownish discoloration was noted, which was more marked on the dorsal aspect of the hands (Figure 1)

In aggregate, it is likely that NNMT enhances SIRT1 activity by decreasing NAM and increasing 1-MNAM, and enhances PARP1 activity by consuming NAM

Researchers planning protocols are referred to the original primary literature cited in the References section for full methodological detail

Lund et al., 2012)

It is commonly chosen by clients who have plateaued with traditional weight-loss methods and want a science-backed, metabolic approach to improving body composition