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3.3.3.3 Inhibition of the JAK-STAT signaling pathway The janus kinase/signal transducer and activator of tranions (JAK/STAT) is a common signaling pathway for transducing signals from various cytokines, which widely regulate cell growth, differentiation, inflammation, apoptosis, and other mechanisms

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The underlying mechanisms of the actions of sulforaphane on cytochrome P450 expression is unclear, but may relate in part to cross-talk between the Nrf2 and Aryl hydrocarbon receptor (Ahr) pathways 26

In particular, for neuroendocrine PCa (NEPC), it uncovered potential antigens by leveraging the Isoform peptides derived from RNA splicing through the Immunotherapy target Screening (IRIS) platform (Pan et al., 2023)