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Description

Somewhat contradictory to the observations in animals, Savage et al (56) reported 27 prepubertal children with severe GH insensitivity syndrome (GHIS or Severe Primary IGF Deficiency (SPIGFD)) to have a median (range) birth weight SDS of -0.72 (1.75 - (-3.29)) and birth length SDS of -1.59 (0.63 - (-3.63))

This typically subsides as the body adjusts and can be managed by staying well-hydrated and monitoring sodium intake

H&E staining was performed using a standardized protocol ( Statistical Analysis All values are expressed as means SEM and were analyzed using one-way analysis of variance (ANOVA) followed by Tukeys method for post hoc analysis