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reverse primer: 5-CATAGGCAATGAAGTCAACATAAGT-3) for HrGSTm1 double-stranded RNA (dsRNA) and green fluorescent protein (GFP) (forward primer: 5-TAATACGACTCACTATAGGG GACGTAAACGGCCACAAGT-3
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To date, sorafenib and lenvatinib, two multi-kinase inhibitors, remain the first-line therapeutic agents for advanced HCC, showing significant efficacy in decrease disease progression [19, 20]
Crossing these Jnk1 LoxP/LoxP / Jnk2 -/- mice with Alb-Cre mice produced Jnk hepa ( Jnk hepa mice developed higher liver injury than wild-type animals after APAP overdose, suggesting a beneficial role for combined Jnk1 and Jnk2 activation in hepatocytes during APAP-induced hepatotoxicity
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