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To uncover the underlying mechanisms, the researchers analyzed hippocampal tissue focusing on dentate gyrus, where they quantified neural progenitor proliferation and neurogenesis through BrdU, immunofluorescence for Sox2, GFAP, DCX and NeuN, and unbiased stereological cell counting

Additionally, the development of condition - responsive hydrogels, such as those responsive to oxidative stress or pH changes, can enable precise release when needed in the intervertebral disc environment, which is a promising direction for future development