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Grober U, Kisters K, Schmidt J

ET and WR worked on the data analysis and revisions of the manuscript

Hypoxia induces the overexpression of Hilpda, which leads to triglyceride overload and FAO defects by downregulating adipose triglyceride lipase (ATGL), triggering mitochondrial dysfunction and upregulating profibrotic factors (TGF-1, -SMA, type I collagen) while reducing the expression of cyclin-dependent kinase 1 (CDK1) and increasing the CyclinB1/D1 ratio, collectively promoting renal tubular fibrosis [85]

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[DOI] [PubMed] [Google Scholar] 62.Anderson JM, Van Itallie CM