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Spheroids replicate more accurately the extracellular environment in vivo as compared to standard 2D cell cultures, including cell-to-cell and cell-matrix interactions and cell signaling pathways [41]

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The monosaccharides leave these cells via facilitated diffusion and enter the capillaries through intercellular clefts

Silvestri, C

This arrangement gives the overall molecule an area described as its head (the phosphate-containing group), which has a polar character or negative charge, and an area called the tail (the fatty acids), which has no charge