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doi: 10.1016/j.aggp.2025.100185 118 TabernaM.Gil MoncayoF.Jan-SalasE.AntonioM.ArribasL.VilajosanaE.et al

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[DOI] [PMC free article] [PubMed] [Google Scholar] UNDP (United Nations Development Programme)

Methionine sulfoxide can be subsequently reduced back to methionine by specific reductases, thereby restoring A1ATs functionality and enabling continuous ROS scavenging ( Beside the described scavenging effect, however, oxidation of methionine residues leads to a decrease in the protective effect of A1AT as a protease inhibitor ( For this reason, an increasing number of studies reports the development of engineered forms of A1AT, with amino acid substitution at methionine 351 and 358, designed to keep the anti-protease activity, even in a oxidative microenvironment ( Additionally, the cysteine residues in A1AT may undergo oxidation, which decreases ROS levels

02 Healing Support Enhances wound recovery and reduces scar formation