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The first, rate-limiting step involves the ligation of cysteine to glutamate to form -glutamylcysteine, catalyzed by -glutamylcysteine ligase (GCL)
In another human intervention trial, healthy volunteers were intravenously injected with 1 mg of the CYP3A4 substrate midazolam and its area under the plasma concentrationtime curve (AUC) was determined before and after a 3-week intervention with 750 IU (503 mg) RRR-T/d orally or placebo (six subjects per group)
Although adenosine deaminase is widely distributed in mammalian tissues, highest levels are found in lymphoid tissue: levels in circulating T cells (particularly in T cell lymphoblastic leukemia) are higher than those in B cells
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