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Intracellular glutathione concentration measured in the cell lines showed a significant (P = 0.05) correlation with IC50 values for cisplatin (r = 0.91), carboplatin (r = 0.87) and CHIP (r = 0.88)

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Metformin use is also associated with modulation of energy balance resulting in weight loss

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doi: 10.1016/j.tips.2008.05.001
