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Never double-dose to compensate the additive hypoglycemia risk outweighs any signaling benefit

MarginaD.GradinaruD.MitreaN.2009Development of a potentiometric method for the evaluation of redox status in human serum54145 EOF48 EOF0035-3930 60
Lin et al., 2020

Therefore, GH-independent mechanisms, in particular Wnt signaling, seem to be key for controlling local IGF1 expression in articular cartilage

& Jaffe, G
