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Recent meta-analyses have suggested regional as well as stage-specific differences in levels of glutamate and/or Glx ( As ScZ can be preceded by a prodromal period of up to 5 years during which attenuated psychotic symptoms (APS) as well as behavioral and cognitive changes already exist ( Few MRS studies, however, have investigated sensory areas, such as auditory regions, despite the fact that auditory cortex functioning is of crucial importance for understanding circuit dysfunctions in ScZ, given the profound disruptions in auditory processing that involve impaired perception of stimulus features ( In the current study, we therefore examined GABA, glutamate and Glx levels in right and left auditory cortex, in a sample of 99 anti-psychotic medication nave CHR-P participants, 32 participants with affective disorders and substance abuse disorders (CHR-N), and 45 healthy controls (HC)

doi: 10.7150/THNO.52028 52 ZhaoPSongHGaoFChenLQiuJJinJet al

Nissl staining was assessed on day 5, and the results showed an obvious decrease in the infarct size between the PT group and the PT-allicin group (Fig