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The latter may be caused by intestinal disorders, infections, bariatric surgery, or pharmacological interference, including histamine H2 receptor antagonists and metformin

It appeared, as a peptide native and stable in human gastric juice, as a late outbreak of the cytoprotection/organoprotection concept of Robert and Szabo, a concept mostly from the stomach studies [10,11,12,13,14,15,16,17] for epithelial and endothelial protection, like the previous theoretical/practical breakthroughs in the 1980s and braingut axis and gutbrain axis (for review, see, i.e., [2,3,4,5,6,7,8])

Harder BG, Blomquist MR, Wang J, Kim AJ, Woodworth GF, Winkles JA, Loftus JC, Tran NL