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Rather than acting directly on tight junction proteins, irradiation primarily perturbs their abundance and subcellular localization through oxidative stress and inflammatory reprogramming, including through NF-B-dependent signaling cascades, as well as miRNA-mediated posttranscriptional regulation, ultimately leading to reduced ZO-1 and claudin-3 expression and compromised epithelial barrier integrity 61

Therefore, focusing this chapter on TYRI-bearing heterocycles proves to be valuable and inspirational for the scientific community, as it offers insights for designing new generations of molecules capable of inhibiting or even degrading tyrosinase
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