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Cisplatin can directly combine with GSH to form a Pt (platinum)-GSH complex, leading to the inactivation of GSH and GXP4, thereby promoting ferroptosis

Discussion Our analysis did not show a major gene effect of either the MTHFR C677T polymorphism or GSTO-1 C419A polymorphism on the volume of the ischemic infarct

APOE genotype predicts whennot whetherone is predisposed to develop Alzheimer disease

To determine whether this effect is preserved in non-human primate, we tested the oral administration of SC-919 in normal monkeys, and showed that 0.3 and 3 mg/kg SC-919 was significantly effective in lowering the plasma phosphate levels (Fig