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doi:10.1016/j.jep.2020.113434

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ALC has also been shown to increase the hippocampal binding of glucocorticoids and nerve growth factor [25], to reduce the oxidative stress, and to inhibit the excitotoxicity in brain tissue and CSF, thus preventing cell death and ischemia-induced neuronal damage [26,27]

Sigma-Aldrich, USA) at pH 7.4 in static 24-well plates (Corning CoStar, USA) for 4, 24 or 48 h at 37C

The dose and duration-dependent association between melatonin treatment and overall cognition in Alzheimers dementia: a network meta- analysis of randomized placebo-controlled trials