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3c), compounds 1 - 5 were found to be slow inhibitors as they displayed little to no inhibition after 15 min, but time-dependent inhibition of TGR over 25 h (Fig

Additionally, they induce hyperphosphorylation of these proteins via the activation of kinases such as protein kinase C or inhibition of phosphatases such as PP2A, further weakening the structural integrity of the tight junction complex (Figure 3) [167,168]

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Phytochelatins and metallothioneins: roles in heavy metal detoxification and homeostasis