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(69) demonstrated that 14-day exposure to a eucaloric very-low-carbohydrate ketogenic diet as adjuvant treatment to first-generation somatostatin receptor ligands decreased IGF-I without increasing GH levels in acromegaly patients

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Furthermore, a study found that cyclodextrin (-CD) greatly increases the solubility of drugs in combinations comprising acidic non-steroidal anti-inflammatory drugs and basic H2 blockers such as indomethacin-imidazole, histidine-imidazole where the solubility of the drug is enhanced by the interaction between the drugs