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Typically, individuals who benefit the most from B12 vitamin injections are those experiencing symptoms of B12 deficiency, which can include chronic fatigue, weakness, mood changes, memory issues, or tingling in the hands and feet

Note on humans: These benefits are not established in humans no completed clinical trials exist [1]

Cautious use of parenteral cyanocobalamin is also recommended in patients with renal impairment, including premature neonates, because of the possibility of greater aluminum accumulation, which may cause central nervous system and bone toxicity

The mechanisms are complementary, making this combination theoretically rational

10.3390/biom9010034 110 PrzyborowskiK.WojewodaM.SitekB.ZakrzewskaA.KijA.WandzelK.et al (2015)