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Central NMU signaling in body weight and energy balance regulation: evidence from NMUR2 deletion and chronic central NMU treatment in mice

MICC: Contains methionine, inositol, choline, and B12

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Studies found that fat mass reduction occurred without corresponding losses in lean tissue, indicating a muscle-sparing effect

It remains unclear how these extrinsic and intrinsic changes are integrated systematically and how heterogeneities related to cellular senescence within both myogenic and non-myogenic cell populations contribute, in part due to a paucity of holistic analyses of these alterations