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Native amylin is chemically unstable and aggregation-prone, which is why the clinically used first-generation amylin drug pramlintide requires multiple daily injections

Overdose of certain B vitamins can cause symptoms such as gastrointestinal upset, skin lesions, or neurological abnormalities

However, before deciding to go forward with these enzymes, the pathway was analysed by Equilibrator [3] to observe the feasibility and potential bottleneck of the whole cascade, along with the free energy analysis under physiological conditions

Leng Y, Musiek ES, Hu K, Cappuccio FP, Yaffe K

GH-releasing hormone and GH-releasing peptide-6 for diagnostic testing in GH-deficient adults