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Model stability was assessed by excluding random effects and comparing the estimates derived with those derived for the full data set, indicating no influential random effects

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556 Consequently, researchers believe that HIF-1 may serve as a mechanism for cells to rapidly respond to acute hypoxia, whereas HIF-2 may be more relevant in chronic hypoxic responses

Sample acquisition was performed using either the LSR Fortessa or Symphony flow cytometers (BD), and data was analyzed using FlowJo software (BD)